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4ib4

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==Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine==
==Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine==
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<StructureSection load='4ib4' size='340' side='right' caption='[[4ib4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4ib4' size='340' side='right'caption='[[4ib4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ib4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IB4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ib4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IB4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">5HT2B_HUMAN, cybC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ib4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ib4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ib4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ib4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ib4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ib4 OCA], [https://pdbe.org/4ib4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ib4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ib4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ib4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ib4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Cherezov, V]]
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[[Category: Homo sapiens]]
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[[Category: Chu, M]]
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[[Category: Large Structures]]
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[[Category: GPCR, GPCR Network]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Han, G W]]
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[[Category: Serotonin Receptor]]
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[[Category: Huang, X]]
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[[Category: Cherezov V]]
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[[Category: Jiang, Y]]
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[[Category: Chu M]]
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[[Category: Katritch, V]]
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[[Category: Han GW]]
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[[Category: Liu, W]]
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[[Category: Huang X]]
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[[Category: McCorvy, J D]]
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[[Category: Jiang Y]]
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[[Category: Roth, B L]]
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[[Category: Katritch V]]
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[[Category: Siu, F Y]]
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[[Category: Liu W]]
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[[Category: Stevens, R C]]
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[[Category: McCorvy JD]]
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[[Category: Vardy, E]]
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[[Category: Roth BL]]
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[[Category: Wacker, D]]
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[[Category: Siu FY]]
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[[Category: Wang, C]]
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[[Category: Stevens RC]]
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[[Category: Xu, H E]]
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[[Category: Vardy E]]
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[[Category: Electron transport]]
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[[Category: Wacker D]]
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[[Category: Ergotamine]]
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[[Category: Wang C]]
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[[Category: Gpcr]]
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[[Category: Xu HE]]
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[[Category: Gpcr dock]]
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[[Category: Gpcr network]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine

PDB ID 4ib4

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