This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4igh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:22, 20 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog==
==High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog==
-
<StructureSection load='4igh' size='340' side='right' caption='[[4igh]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+
<StructureSection load='4igh' size='340' side='right'caption='[[4igh]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4igh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IGH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4igh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IGH FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EA:6-FLUORO-2-[2-METHYL-4-PHENOXY-5-(PROPAN-2-YL)PHENYL]QUINOLINE-4-CARBOXYLIC+ACID'>1EA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=ZWI:3-[DECYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE'>ZWI</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EA:6-FLUORO-2-[2-METHYL-4-PHENOXY-5-(PROPAN-2-YL)PHENYL]QUINOLINE-4-CARBOXYLIC+ACID'>1EA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=ZWI:3-[DECYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE'>ZWI</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4igh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igh OCA], [https://pdbe.org/4igh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4igh RCSB], [https://www.ebi.ac.uk/pdbsum/4igh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4igh ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igh OCA], [http://pdbe.org/4igh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4igh RCSB], [http://www.ebi.ac.uk/pdbsum/4igh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4igh ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
+
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
==See Also==
==See Also==
-
*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
+
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Brabander, J K.De]]
+
[[Category: Large Structures]]
-
[[Category: Das, P]]
+
[[Category: Das P]]
-
[[Category: Deng, X]]
+
[[Category: De Brabander JK]]
-
[[Category: Fontoura, B M.A]]
+
[[Category: Deng X]]
-
[[Category: Phillips, M A]]
+
[[Category: Fontoura BMA]]
-
[[Category: Anti-viral]]
+
[[Category: Phillips MA]]
-
[[Category: Dehydrogenase]]
+
-
[[Category: Fmn]]
+
-
[[Category: Membrane]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+
-
[[Category: Quinoline-4-carboxylic acid]]
+
-
[[Category: Redox]]
+

Current revision

High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog

PDB ID 4igh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4igh"
Personal tools