This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4jjh
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]== | |
| + | <StructureSection load='4jjh' size='340' side='right'caption='[[4jjh]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jjh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjh OCA], [https://pdbe.org/4jjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jjh RCSB], [https://www.ebi.ac.uk/pdbsum/4jjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Ectodermal dysplasia-syndactyly syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.<ref>PMID:22048310</ref> <ref>PMID:23202587</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ahmed M]] | ||
| + | [[Category: Almo SC]] | ||
| + | [[Category: Banu R]] | ||
| + | [[Category: Bhosle R]] | ||
| + | [[Category: Bonanno J]] | ||
| + | [[Category: Calarese D]] | ||
| + | [[Category: Celikigil A]] | ||
| + | [[Category: Chamala S]] | ||
| + | [[Category: Chan MK]] | ||
| + | [[Category: Chowdhury S]] | ||
| + | [[Category: Fiser A]] | ||
| + | [[Category: Garforth S]] | ||
| + | [[Category: Glenn AS]] | ||
| + | [[Category: Hillerich B]] | ||
| + | [[Category: Khafizov K]] | ||
| + | [[Category: Kumar PR]] | ||
| + | [[Category: Love J]] | ||
| + | [[Category: Nathenson SG]] | ||
| + | [[Category: Patel H]] | ||
| + | [[Category: Seidel R]] | ||
| + | [[Category: Stead M]] | ||
| + | [[Category: Toro R]] | ||
Current revision
Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]
| |||||||||||
Categories: Homo sapiens | Large Structures | Ahmed M | Almo SC | Banu R | Bhosle R | Bonanno J | Calarese D | Celikigil A | Chamala S | Chan MK | Chowdhury S | Fiser A | Garforth S | Glenn AS | Hillerich B | Khafizov K | Kumar PR | Love J | Nathenson SG | Patel H | Seidel R | Stead M | Toro R
