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4jlf

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==Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase==
==Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase==
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<StructureSection load='4jlf' size='340' side='right' caption='[[4jlf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4jlf' size='340' side='right'caption='[[4jlf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jlf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JLF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jlf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JLF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gdn|2gdn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaA, blaC, Rv2068c, MT2128, MTCY49.07c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlf OCA], [https://pdbe.org/4jlf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jlf RCSB], [https://www.ebi.ac.uk/pdbsum/4jlf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jlf ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jlf RCSB], [http://www.ebi.ac.uk/pdbsum/4jlf PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAC_MYCTU BLAC_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4jlf" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Blanchard, J]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Bonomo, R]]
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[[Category: Blanchard J]]
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[[Category: Hazra, S]]
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[[Category: Bonomo R]]
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[[Category: Kurz, S]]
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[[Category: Hazra S]]
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[[Category: Beta-lactams inactivation]]
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[[Category: Kurz S]]
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[[Category: Drug design]]
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[[Category: Hydrolase]]
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[[Category: Multi drug resistance]]
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[[Category: Tuberculosis]]
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Current revision

Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase

PDB ID 4jlf

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