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4js9
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| - | {{STRUCTURE_4js9| PDB=4js9 | SCENE= }} | ||
| - | ===Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme=== | ||
| - | == | + | ==Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme== |
| - | [[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE | + | <StructureSection load='4js9' size='340' side='right'caption='[[4js9]], [[Resolution|resolution]] 2.78Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4js9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.784Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=MH0:MESOHEME'>MH0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js9 OCA], [https://pdbe.org/4js9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js9 RCSB], [https://www.ebi.ac.uk/pdbsum/4js9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Bolisetty K]] |
| - | [[Category: | + | [[Category: Hannibal L]] |
| - | [[Category: | + | [[Category: Misra S]] |
| - | [[Category: | + | [[Category: Page RC]] |
| - | [[Category: | + | [[Category: Stuehr DJ]] |
| - | + | [[Category: Yu Z]] | |
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Current revision
Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme
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Categories: Large Structures | Mus musculus | Bolisetty K | Hannibal L | Misra S | Page RC | Stuehr DJ | Yu Z
