4jwc

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==Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16)==
==Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16)==
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<StructureSection load='4jwc' size='340' side='right' caption='[[4jwc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4jwc' size='340' side='right'caption='[[4jwc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jwc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JWC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jwc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JWC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dkx|1dkx]], [[1dky|1dky]], [[1dkz|1dkz]], [[3dpo|3dpo]], [[3dpp|3dpp]], [[3dpq|3dpq]], [[3qnj|3qnj]], [[4e81|4e81]], [[4jwd|4jwd]], [[4jwe|4jwe]], [[4jwi|4jwi]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaK, groP, grpF, seg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jwc OCA], [https://pdbe.org/4jwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jwc RCSB], [https://www.ebi.ac.uk/pdbsum/4jwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jwc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jwc OCA], [http://pdbe.org/4jwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jwc RCSB], [http://www.ebi.ac.uk/pdbsum/4jwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jwc ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/CTHL3_BOVIN CTHL3_BOVIN]] Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.
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[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Bos taurus]]
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[[Category: Straeter, N]]
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[[Category: Escherichia coli K-12]]
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[[Category: Zahn, M]]
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[[Category: Large Structures]]
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[[Category: Antimicrobial peptide]]
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[[Category: Straeter N]]
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[[Category: Chaperone]]
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[[Category: Zahn M]]
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[[Category: Chaperone-antibiotic complex]]
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[[Category: Chaperone-protein binding complex]]
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[[Category: Peptide binding]]
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[[Category: Peptide binding protein]]
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Current revision

Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(1-16)

PDB ID 4jwc

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