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4k0g

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==Crystal structure of human CLIC1 C24S mutant==
==Crystal structure of human CLIC1 C24S mutant==
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<StructureSection load='4k0g' size='340' side='right' caption='[[4k0g]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='4k0g' size='340' side='right'caption='[[4k0g]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4k0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K0G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4k0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K0G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jzq|4jzq]], [[4k0n|4k0n]], [[4k1d|4k1d]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLIC1, CLIC1 G6 NCC27, G6, NCC27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0g OCA], [https://pdbe.org/4k0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k0g RCSB], [https://www.ebi.ac.uk/pdbsum/4k0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0g OCA], [http://pdbe.org/4k0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k0g RCSB], [http://www.ebi.ac.uk/pdbsum/4k0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0g ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Curmi, P M.G]]
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[[Category: Large Structures]]
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[[Category: Duff, A P]]
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[[Category: Curmi PMG]]
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[[Category: Harrop, S J]]
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[[Category: Duff AP]]
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[[Category: Phang, J M]]
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[[Category: Harrop SJ]]
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[[Category: Wilk, K E]]
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[[Category: Phang JM]]
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[[Category: Chloride ion channel]]
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[[Category: Wilk KE]]
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[[Category: Clic]]
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[[Category: Glutathione-s-transferase fold]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of human CLIC1 C24S mutant

PDB ID 4k0g

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