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4kgq

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==Crystal structure of a human light loop mutant in complex with dcr3==
==Crystal structure of a human light loop mutant in complex with dcr3==
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<StructureSection load='4kgq' size='340' side='right' caption='[[4kgq]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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<StructureSection load='4kgq' size='340' side='right'caption='[[4kgq]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kgq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kgq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KGQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4en0|4en0]], [[3k51|3k51]], [[3mi8|3mi8]], [[3mhd|3mhd]], [[4j6g|4j6g]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF6B, DCR3, TR6, UNQ186/PRO212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgq OCA], [https://pdbe.org/4kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kgq RCSB], [https://www.ebi.ac.uk/pdbsum/4kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kgq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kgq RCSB], [http://www.ebi.ac.uk/pdbsum/4kgq PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
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[https://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kgq" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
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*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Almo, S C]]
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[[Category: Large Structures]]
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[[Category: Bonanno, J B]]
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[[Category: Almo SC]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
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[[Category: Bonanno JB]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: Structural genomic]]
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[[Category: Nathenson SG]]
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[[Category: Nathenson, S G]]
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[[Category: Sampathkumar P]]
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[[Category: Sampathkumar, P]]
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[[Category: Toro R]]
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[[Category: Toro, R]]
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[[Category: Zhan C]]
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[[Category: Zhan, C]]
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[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Bind tnf receptor hvem and ltbr]]
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[[Category: Cytokine]]
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[[Category: Dcr3]]
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[[Category: Ifn]]
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[[Category: Immune system]]
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[[Category: Jelly-roll fold]]
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[[Category: Light]]
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[[Category: Ltbr]]
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[[Category: Membrane]]
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[[Category: N-glycosylation]]
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[[Category: New hvem]]
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[[Category: Nysgrc]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Secreted protein]]
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[[Category: Tnf]]
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[[Category: Tnf14]]
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[[Category: Tnfr]]
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Current revision

Crystal structure of a human light loop mutant in complex with dcr3

PDB ID 4kgq

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