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4kk2

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{{STRUCTURE_4kk2| PDB=4kk2 | SCENE= }}
 
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===Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure===
 
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==Function==
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==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure==
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[[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref>
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<StructureSection load='4kk2' size='340' side='right'caption='[[4kk2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KK2 FirstGlance]. <br>
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[[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [https://pdbe.org/4kk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4kk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk2 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/FPPS1_ARTSI FPPS1_ARTSI] Catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) with the allylic pyrophosphates, dimethylallyl pyrophosphate (DMAPP), and then with the resultant geranylpyrophosphate (GPP) to the ultimate product farnesyl pyrophosphate (FPP). Has a 4.5 time greater affinity for GPP versus DMAPP.<ref>PMID:12782626</ref> [https://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Artemisia spiciformis]]
[[Category: Artemisia spiciformis]]
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Bhosle, R.]]
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[[Category: Al Obaidi NF]]
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[[Category: Chowdhury, S.]]
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[[Category: Almo SC]]
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[[Category: Evans, B.]]
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[[Category: Bhosle R]]
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[[Category: Gerlt, J A.]]
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[[Category: Chowdhury S]]
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[[Category: Glenn, A Scott.]]
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[[Category: Evans B]]
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[[Category: Hammonds, J.]]
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[[Category: Gerlt JA]]
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[[Category: Hillerich, B.]]
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[[Category: Hammonds J]]
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[[Category: Imker, H J.]]
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[[Category: Hillerich B]]
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[[Category: Initiative, Enzyme Function.]]
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[[Category: Imker HJ]]
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[[Category: Love, J.]]
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[[Category: Love J]]
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[[Category: Obaidi, N F.Al.]]
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[[Category: Poulter CD]]
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[[Category: Poulter, C D.]]
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[[Category: Scott Glenn A]]
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[[Category: Seidel, R D.]]
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[[Category: Seidel RD]]
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[[Category: Toro, R.]]
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[[Category: Toro R]]
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[[Category: Vetting, M W.]]
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[[Category: Vetting MW]]
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[[Category: Washington, E.]]
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[[Category: Washington E]]
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[[Category: Enzyme function initiative]]
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[[Category: Isoprenoid synthase]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure

PDB ID 4kk2

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