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4klz
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4klz is ON HOLD Authors: Shah, D.M., Kobayashi, M., Keizers, P.H, Tuin, A.W., Ab, E., Manning, L., Rzepiela, A.A., Andrews, M., Hoedemaeker, F.J., S...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis== | |
| - | + | <StructureSection load='4klz' size='340' side='right'caption='[[4klz]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4klz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klz OCA], [https://pdbe.org/4klz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klz RCSB], [https://www.ebi.ac.uk/pdbsum/4klz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Noonan syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<ref>PMID:15632082</ref> <ref>PMID:23791108</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ab E]] | ||
| + | [[Category: Andrews M]] | ||
| + | [[Category: Hoedemaeker FJ]] | ||
| + | [[Category: Keizers PH]] | ||
| + | [[Category: Kobayashi M]] | ||
| + | [[Category: Manning L]] | ||
| + | [[Category: Rzepiela AA]] | ||
| + | [[Category: Shah DM]] | ||
| + | [[Category: Siegal G]] | ||
| + | [[Category: Tuin AW]] | ||
Current revision
Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
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Categories: Homo sapiens | Large Structures | Ab E | Andrews M | Hoedemaeker FJ | Keizers PH | Kobayashi M | Manning L | Rzepiela AA | Shah DM | Siegal G | Tuin AW
