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4ktt

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==Structural insights of MAT enzymes: MATa2b complexed with SAM==
==Structural insights of MAT enzymes: MATa2b complexed with SAM==
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<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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<StructureSection load='4ktt' size='340' side='right'caption='[[4ktt]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2p02|2p02]], [[2ydx|2ydx]], [[4ktv|4ktv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [https://pdbe.org/4ktt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [https://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. [[http://www.uniprot.org/uniprot/MAT2B_HUMAN MAT2B_HUMAN]] Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.<ref>PMID:10644686</ref>
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[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ktt" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Methionine adenosyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Antonyuk, S V]]
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[[Category: Large Structures]]
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[[Category: Hasnain, S S]]
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[[Category: Antonyuk SV]]
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[[Category: Lu, S C]]
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[[Category: Hasnain SS]]
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[[Category: Marina, A]]
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[[Category: Lu SC]]
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[[Category: Mato, J M]]
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[[Category: Marina A]]
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[[Category: Murray, B]]
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[[Category: Mato JM]]
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[[Category: Rojas, A L]]
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[[Category: Murray B]]
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[[Category: Same synthesis]]
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[[Category: Rojas AL]]
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[[Category: Transferase]]
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Current revision

Structural insights of MAT enzymes: MATa2b complexed with SAM

PDB ID 4ktt

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