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4kww

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==The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid==
==The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid==
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<StructureSection load='4kww' size='340' side='right' caption='[[4kww]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='4kww' size='340' side='right'caption='[[4kww]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kww]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KWW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KWW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kww]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KWW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHT:PHTHALIC+ACID'>PHT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kwv|4kwv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PHT:PHTHALIC+ACID'>PHT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">QPRT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kww OCA], [https://pdbe.org/4kww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kww RCSB], [https://www.ebi.ac.uk/pdbsum/4kww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kww ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kww OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kww RCSB], [http://www.ebi.ac.uk/pdbsum/4kww PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NADC_HUMAN NADC_HUMAN]] Involved in the catabolism of quinolinic acid (QA).<ref>PMID:17868694</ref>
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[https://www.uniprot.org/uniprot/NADC_HUMAN NADC_HUMAN] Involved in the catabolism of quinolinic acid (QA).<ref>PMID:17868694</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kww" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Dimeka, P N]]
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[[Category: Large Structures]]
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[[Category: Malik, S S]]
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[[Category: Dimeka PN]]
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[[Category: Ncube, Z]]
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[[Category: Malik SS]]
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[[Category: Toth, E A]]
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[[Category: Ncube Z]]
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[[Category: Brain]]
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[[Category: Toth EA]]
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[[Category: Metabolism]]
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[[Category: Nad]]
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[[Category: Prpp]]
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[[Category: Quinolinic acid]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Type ii phosphoribosyltransferase]]
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Current revision

The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid

PDB ID 4kww

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