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4kx5

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==Cytosolic 5'-nucleotidase III complexed with cytidine 5'-monophosphate==
==Cytosolic 5'-nucleotidase III complexed with cytidine 5'-monophosphate==
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<StructureSection load='4kx5' size='340' side='right' caption='[[4kx5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4kx5' size='340' side='right'caption='[[4kx5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kx5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KX5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kx5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KX5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fe3|4fe3]], [[2g06|2g06]], [[2g09|2g09]], [[4kx3|4kx3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nt5c3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx5 OCA], [https://pdbe.org/4kx5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kx5 RCSB], [https://www.ebi.ac.uk/pdbsum/4kx5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx5 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kx5 OCA], [http://pdbe.org/4kx5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kx5 RCSB], [http://www.ebi.ac.uk/pdbsum/4kx5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kx5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5NT3_MOUSE 5NT3_MOUSE]] Can act both as nucleotidase and as phosphotransferase (By similarity).
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[https://www.uniprot.org/uniprot/5NT3A_MOUSE 5NT3A_MOUSE] Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.[UniProtKB:Q9H0P0]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5'-nucleotidase]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Bingman, C A]]
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[[Category: Bingman CA]]
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[[Category: Bitto, E]]
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[[Category: Bitto E]]
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[[Category: Grobosky, C L]]
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[[Category: Grobosky CL]]
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[[Category: Cytosolic 5'-nucleotidase iii]]
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[[Category: Had superfamily]]
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[[Category: Hydrolase]]
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[[Category: Nucleotidase]]
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[[Category: P5n-1]]
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[[Category: Substrate complex]]
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[[Category: Umph-1]]
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Current revision

Cytosolic 5'-nucleotidase III complexed with cytidine 5'-monophosphate

PDB ID 4kx5

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