4l4t
From Proteopedia
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==Structure of human MAIT TCR in complex with human MR1-6-FP== | ==Structure of human MAIT TCR in complex with human MR1-6-FP== | ||
| - | <StructureSection load='4l4t' size='340' side='right' caption='[[4l4t]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4l4t' size='340' side='right'caption='[[4l4t]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4l4t]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4l4t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4T FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FP:2-AMINO-4-OXO-3,4-DIHYDROPTERIDINE-6-CARBALDEHYDE'>6FP</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4t OCA], [https://pdbe.org/4l4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4t RCSB], [https://www.ebi.ac.uk/pdbsum/4l4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4t ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| - | *[[T-cell receptor|T-cell receptor]] | + | *[[T-cell receptor 3D structures|T-cell receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Beddoe | + | [[Category: Large Structures]] |
| - | [[Category: Birkinshaw | + | [[Category: Beddoe T]] |
| - | [[Category: Brooks | + | [[Category: Birkinshaw RW]] |
| - | [[Category: Chen | + | [[Category: Brooks AG]] |
| - | [[Category: Corbett | + | [[Category: Chen Z]] |
| - | [[Category: Eckle | + | [[Category: Corbett AJ]] |
| - | [[Category: Fairlie | + | [[Category: Eckle SBG]] |
| - | [[Category: Kjer-Nielsen | + | [[Category: Fairlie DP]] |
| - | [[Category: Liu | + | [[Category: Kjer-Nielsen L]] |
| - | [[Category: McCluskey | + | [[Category: Le Nours J]] |
| - | [[Category: Meehan | + | [[Category: Liu L]] |
| - | [[Category: Miles | + | [[Category: McCluskey J]] |
| - | + | [[Category: Meehan B]] | |
| - | [[Category: Patel | + | [[Category: Miles JJ]] |
| - | [[Category: Reantragoon | + | [[Category: Patel O]] |
| - | [[Category: Rossjohn | + | [[Category: Reantragoon R]] |
| - | [[Category: Sandoval-Romero | + | [[Category: Rossjohn J]] |
| - | [[Category: Sullivan | + | [[Category: Sandoval-Romero ML]] |
| - | + | [[Category: Sullivan LC]] | |
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Current revision
Structure of human MAIT TCR in complex with human MR1-6-FP
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Categories: Homo sapiens | Large Structures | Beddoe T | Birkinshaw RW | Brooks AG | Chen Z | Corbett AJ | Eckle SBG | Fairlie DP | Kjer-Nielsen L | Le Nours J | Liu L | McCluskey J | Meehan B | Miles JJ | Patel O | Reantragoon R | Rossjohn J | Sandoval-Romero ML | Sullivan LC
