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4l6r

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==Structure of the class B human glucagon G protein coupled receptor==
==Structure of the class B human glucagon G protein coupled receptor==
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<StructureSection load='4l6r' size='340' side='right' caption='[[4l6r]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='4l6r' size='340' side='right'caption='[[4l6r]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l6r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L6R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Glucagon'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_4 10.2210/rcsb_pdb/mom_2015_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L6R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cybC, GCGR_Human, GCGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l6r RCSB], [http://www.ebi.ac.uk/pdbsum/4l6r PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6r OCA], [https://pdbe.org/4l6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6r RCSB], [https://www.ebi.ac.uk/pdbsum/4l6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/GLR_HUMAN GLR_HUMAN] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4l6r" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Cherezov, V]]
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[[Category: Glucagon]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Homo sapiens]]
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[[Category: Graaf, C de]]
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[[Category: Large Structures]]
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[[Category: Han, G W]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: He, M]]
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[[Category: Cherezov V]]
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[[Category: Joseph, J S]]
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[[Category: Han GW]]
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[[Category: Katritch, V]]
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[[Category: He M]]
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[[Category: Lau, J]]
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[[Category: Joseph JS]]
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[[Category: Liu, W]]
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[[Category: Katritch V]]
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[[Category: Siu, F Y]]
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[[Category: Lau J]]
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[[Category: Stevens, R C]]
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[[Category: Liu W]]
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[[Category: Wacker, D]]
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[[Category: Siu FY]]
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[[Category: Wang, M W]]
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[[Category: Stevens RC]]
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[[Category: Xu, Q]]
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[[Category: Wacker D]]
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[[Category: Yang, D]]
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[[Category: Wang MW]]
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[[Category: Zhang, Z]]
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[[Category: Xu Q]]
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[[Category: Zhou, C]]
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[[Category: Yang D]]
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[[Category: Diabetes]]
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[[Category: Zhang Z]]
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[[Category: Gpcr]]
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[[Category: Zhou C]]
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[[Category: Gpcr network]]
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[[Category: De Graaf C]]
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[[Category: Human glucagon receptor]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Structure of the class B human glucagon G protein coupled receptor

PDB ID 4l6r

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