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4l7g

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{{STRUCTURE_4l7g| PDB=4l7g | SCENE= }}
 
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===Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)===
 
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==Function==
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==Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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<StructureSection load='4l7g' size='340' side='right'caption='[[4l7g]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W0:(3AS,7AR)-7A-[3-(PYRIMIDIN-5-YL)PHENYL]-3A,6,7,7A-TETRAHYDRO-4H-PYRANO[4,3-D][1,3]OXAZOL-2-AMINE'>1W0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7g OCA], [https://pdbe.org/4l7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7g RCSB], [https://www.ebi.ac.uk/pdbsum/4l7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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==About this Structure==
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==See Also==
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[[4l7g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7G OCA].
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Large Structures]]
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[[Category: Do, M K.Geck.]]
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[[Category: Dutcher D]]
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[[Category: Dutcher, D.]]
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[[Category: Geck Do MK]]
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[[Category: Huestis, M P.]]
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[[Category: Huestis MP]]
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[[Category: Hunt, K W.]]
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[[Category: Hunt KW]]
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[[Category: Liu, W.]]
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[[Category: Liu W]]
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[[Category: Purkey, H.]]
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[[Category: Purkey H]]
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[[Category: Siu, M.]]
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[[Category: Siu M]]
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[[Category: Smith, D.]]
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[[Category: Smith D]]
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[[Category: Vigers, G.]]
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[[Category: Vigers G]]
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[[Category: Volgraf, M.]]
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[[Category: Volgraf M]]
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[[Category: Wang, W.]]
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[[Category: Wang W]]
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[[Category: Wu, P.]]
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[[Category: Wu P]]
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[[Category: Yu, C.]]
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[[Category: Yu C]]
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[[Category: Aspartic protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)

PDB ID 4l7g

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