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4log

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==The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with MBP==
==The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with MBP==
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<StructureSection load='4log' size='340' side='right' caption='[[4log]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4log' size='340' side='right'caption='[[4log]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4log]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LOG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4log]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O104:H4_str._2009EL-2071 Escherichia coli O104:H4 str. 2009EL-2071] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LOG FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECDH10B_4223, malE, O3O_01660, NR2E3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4log OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4log RCSB], [http://www.ebi.ac.uk/pdbsum/4log PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4log OCA], [https://pdbe.org/4log PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4log RCSB], [https://www.ebi.ac.uk/pdbsum/4log PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4log ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NR2E3_HUMAN NR2E3_HUMAN] Goldmann-Favre syndrome;Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/NR2E3_HUMAN NR2E3_HUMAN] Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.<ref>PMID:15689355</ref> <ref>PMID:24069298</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4log" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Escherichia coli O104:H4 str. 2009EL-2071]]
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[[Category: Li, J]]
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[[Category: Homo sapiens]]
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[[Category: Li, X]]
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[[Category: Large Structures]]
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[[Category: Melcher, K]]
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[[Category: Li J]]
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[[Category: Soon, F F]]
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[[Category: Li X]]
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[[Category: Tan, M E]]
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[[Category: Melcher K]]
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[[Category: Xu, H E]]
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[[Category: Soon F-F]]
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[[Category: Yong, E L]]
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[[Category: Tan ME]]
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[[Category: Zhou, X E]]
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[[Category: Xu HE]]
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[[Category: Ligand binding domain]]
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[[Category: Yong E-L]]
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[[Category: Orphan nuclear receptor]]
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[[Category: Zhou XE]]
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[[Category: Pnr]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

The crystal structure of the orphan nuclear receptor PNR ligand binding domain fused with MBP

PDB ID 4log

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