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4lv1

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==AmpC beta-lactamase in complex with [1-(3-chlorophenyl)-1H-pyrazol-4-yl] boronic acid==
==AmpC beta-lactamase in complex with [1-(3-chlorophenyl)-1H-pyrazol-4-yl] boronic acid==
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<StructureSection load='4lv1' size='340' side='right' caption='[[4lv1]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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<StructureSection load='4lv1' size='340' side='right'caption='[[4lv1]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lv1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LV1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lv1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LV1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NL9:[1-(3-CHLOROPHENYL)-1H-PYRAZOL-4-YL]BORONIC+ACID'>NL9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lv0|4lv0]], [[4lv2|4lv2]], [[4lv3|4lv3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NL9:[1-(3-CHLOROPHENYL)-1H-PYRAZOL-4-YL]BORONIC+ACID'>NL9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv1 OCA], [https://pdbe.org/4lv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lv1 RCSB], [https://www.ebi.ac.uk/pdbsum/4lv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lv1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv1 OCA], [http://pdbe.org/4lv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lv1 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lv1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Eidam, O]]
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[[Category: Large Structures]]
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[[Category: London, N]]
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[[Category: Eidam O]]
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[[Category: Shoichet, B K]]
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[[Category: London N]]
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[[Category: Ampc beta-lactamase]]
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[[Category: Shoichet BK]]
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[[Category: Boronic acid]]
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[[Category: Class c]]
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[[Category: Covalent inhibitor]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

AmpC beta-lactamase in complex with [1-(3-chlorophenyl)-1H-pyrazol-4-yl] boronic acid

PDB ID 4lv1

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