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4lxj

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==Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound==
==Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound==
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<StructureSection load='4lxj' size='340' side='right' caption='[[4lxj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4lxj' size='340' side='right'caption='[[4lxj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lxj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LXJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lxj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LXJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LAN:LANOSTEROL'>LAN</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERG11, CYP51, YHR007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LAN:LANOSTEROL'>LAN</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lxj OCA], [https://pdbe.org/4lxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lxj RCSB], [https://www.ebi.ac.uk/pdbsum/4lxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lxj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lxj RCSB], [http://www.ebi.ac.uk/pdbsum/4lxj PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CP51_YEAST CP51_YEAST]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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[https://www.uniprot.org/uniprot/CP51_YEAST CP51_YEAST] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4lxj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
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[[Category: Large Structures]]
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[[Category: Sterol 14-demethylase]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Cannon, R D]]
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[[Category: Cannon RD]]
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[[Category: Finer-Moore, J]]
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[[Category: Finer-Moore J]]
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[[Category: Huschmann, F U]]
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[[Category: Huschmann FU]]
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[[Category: III, J D.O Connell]]
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[[Category: Keniya MV]]
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[[Category: Keniya, M V]]
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[[Category: McDonald J]]
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[[Category: McDonald, J]]
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[[Category: Monk BC]]
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[[Category: Monk, B C]]
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[[Category: O'Connell III JD]]
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[[Category: Rodriguez, A]]
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[[Category: Rodriguez A]]
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[[Category: Stroud, R M]]
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[[Category: Stroud RM]]
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[[Category: Tomasiak, T M]]
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[[Category: Tomasiak TM]]
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[[Category: Tyndall, J D.A]]
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[[Category: Tyndall JDA]]
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[[Category: Cytochrome p450]]
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[[Category: Oxidoreductase]]
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Current revision

Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound

PDB ID 4lxj

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