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4m10

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==Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam==
==Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam==
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<StructureSection load='4m10' size='340' side='right' caption='[[4m10]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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<StructureSection load='4m10' size='340' side='right'caption='[[4m10]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m10]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M10 OCA]. <br>
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<table><tr><td colspan='2'>[[4m10]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M10 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ICD:4-HYDROXY-2-METHYL-N-(5-METHYL-1,2-OXAZOL-3-YL)-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE+1,1-DIOXIDE'>ICD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m11|4m11]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ICD:4-HYDROXY-2-METHYL-N-(5-METHYL-1,2-OXAZOL-3-YL)-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE+1,1-DIOXIDE'>ICD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m10 OCA], [https://pdbe.org/4m10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m10 RCSB], [https://www.ebi.ac.uk/pdbsum/4m10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m10 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m10 RCSB], [http://www.ebi.ac.uk/pdbsum/4m10 PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.,Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ J Biol Chem. 2014 Jan 14. PMID:24425867<ref>PMID:24425867</ref>
Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.,Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ J Biol Chem. 2014 Jan 14. PMID:24425867<ref>PMID:24425867</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4m10" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Mus musculus]]
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[[Category: Banerjee, S.]]
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[[Category: Banerjee S]]
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[[Category: Ghebreelasie, K.]]
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[[Category: Ghebreelasie K]]
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[[Category: Hermanson, D J.]]
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[[Category: Hermanson DJ]]
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[[Category: Marnett, L J.]]
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[[Category: Marnett LJ]]
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[[Category: Xu, S.]]
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[[Category: Xu S]]
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[[Category: Cox]]
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[[Category: Dioxygenase]]
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[[Category: Glycosylation]]
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[[Category: Nsaid]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Peroxidase]]
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Current revision

Crystal Structure of Murine Cyclooxygenase-2 Complex with Isoxicam

PDB ID 4m10

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