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4muh

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<StructureSection load='4muh' size='340' side='right'caption='[[4muh]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='4muh' size='340' side='right'caption='[[4muh]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4muh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4muh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DN:[2-({[5-(ACETYLAMINO)-1,3,4-THIADIAZOL-2-YL]SULFONYL}CARBAMOYL)-5-METHOXY-1H-INDOL-1-YL]ACETIC+ACID'>2DN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mq6|4mq6]], [[4mue|4mue]], [[4muf|4muf]], [[4mug|4mug]], [[4mui|4mui]], [[4muj|4muj]], [[4muk|4muk]], [[4mul|4mul]], [[4mun|4mun]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DN:[2-({[5-(ACETYLAMINO)-1,3,4-THIADIAZOL-2-YL]SULFONYL}CARBAMOYL)-5-METHOXY-1H-INDOL-1-YL]ACETIC+ACID'>2DN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3707, MTCY07H7B.20, panC, Rv3602c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4muh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muh OCA], [https://pdbe.org/4muh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4muh RCSB], [https://www.ebi.ac.uk/pdbsum/4muh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4muh ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantoate--beta-alanine_ligase Pantoate--beta-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.1 6.3.2.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muh OCA], [http://pdbe.org/4muh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4muh RCSB], [http://www.ebi.ac.uk/pdbsum/4muh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4muh ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pantoate--beta-alanine ligase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Blundell, T L]]
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[[Category: Blundell TL]]
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[[Category: Silvestre, H L]]
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[[Category: Silvestre HL]]
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[[Category: Atp binding]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Pantoate-ligase]]
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Current revision

Crystal structure of pantothenate synthetase in complex with 2-(2-(5-acetamido-1,3,4-thiadiazol-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid

PDB ID 4muh

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