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4mz3

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==Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant==
==Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant==
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<StructureSection load='4mz3' size='340' side='right' caption='[[4mz3]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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<StructureSection load='4mz3' size='340' side='right'caption='[[4mz3]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZ3 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.741&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mz2|4mz2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCN4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz3 OCA], [https://pdbe.org/4mz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mz3 RCSB], [https://www.ebi.ac.uk/pdbsum/4mz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mz3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz3 OCA], [http://pdbe.org/4mz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mz3 RCSB], [http://www.ebi.ac.uk/pdbsum/4mz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mz3 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN]] Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN] Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN]] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).
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[https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Das, S]]
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[[Category: Large Structures]]
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[[Category: Petegem, F Van]]
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[[Category: Das S]]
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[[Category: Extracellular]]
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[[Category: Van Petegem F]]
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[[Category: Ion conductance]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant

PDB ID 4mz3

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