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4mzc

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{{STRUCTURE_4mzc| PDB=4mzc | SCENE= }}
 
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===Atomic Resolution Structure of PfGrx1===
 
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==About this Structure==
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==Atomic Resolution Structure of PfGrx1==
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[[4mzc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kjf 4kjf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZC OCA].
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<StructureSection load='4mzc' size='340' side='right'caption='[[4mzc]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
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[[Category: Plasmodium falciparum 3d7]]
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== Structural highlights ==
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[[Category: Sharma, A.]]
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<table><tr><td colspan='2'>[[4mzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kjf 4kjf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZC FirstGlance]. <br>
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[[Category: Yogavel, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.949&#8491;</td></tr>
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[[Category: Active site]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene></td></tr>
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[[Category: Glutathione]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mzc OCA], [https://pdbe.org/4mzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mzc RCSB], [https://www.ebi.ac.uk/pdbsum/4mzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mzc ProSAT]</span></td></tr>
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[[Category: Oxidoreductase]]
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</table>
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[[Category: Plasticity]]
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== Function ==
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[[Category: Redox enzyme]]
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[https://www.uniprot.org/uniprot/Q9NLB2_PLAF7 Q9NLB2_PLAF7]
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[[Category: Sulfur-sad]]
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<div style="background-color:#fffaf0;">
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[[Category: Trx fold]]
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== Publication Abstract from PubMed ==
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Glutaredoxins (Grxs) are redox proteins that use glutathione ((gamma)Glu-Cys-Gly; GSH) as a cofactor. Plasmodium falciparum has one classic dithiol (CXXC) glutaredoxin (glutaredoxin 1; PfGrx1) and three monothiol (CXXS) Grx-like proteins (GLPs), which have five residue insertions prior to the active-site Cys. Here, the crystal structure of PfGrx1 has been determined by the sulfur single-wavelength anomalous diffraction (S-SAD) method utilizing intrinsic protein and solvent S atoms. Several residues were modelled with alternate conformations, and an alternate position was refined for the active-site Cys29 owing to radiation damage. The GSH-binding site is occupied by water polygons and buffer molecules. Structural comparison of PfGrx1 with other Grxs and Grx-like proteins revealed that the GSH-binding motifs (CXXC/CXXS, TVP, CDD, Lys26 and Gln/Arg63) are structurally conserved. Both the monothiol and dithiol Grxs possess three conserved water molecules; two of these were located in the GSH-binding site. PfGrx1 has several polar and charged amino-acid substitutions that provide structurally important additional hydrogen bonds and salt bridges missing in other Grxs.
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Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins.,Yogavel M, Tripathi T, Gupta A, Banday MM, Rahlfs S, Becker K, Belrhali H, Sharma A Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):91-100. doi:, 10.1107/S1399004713025285. Epub 2013 Dec 24. PMID:24419382<ref>PMID:24419382</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4mzc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Sharma A]]
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[[Category: Yogavel M]]

Current revision

Atomic Resolution Structure of PfGrx1

PDB ID 4mzc

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