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4nal

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==Arabidopsis thaliana IspD in complex with tribromodichloro-pseudilin==
==Arabidopsis thaliana IspD in complex with tribromodichloro-pseudilin==
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<StructureSection load='4nal' size='340' side='right' caption='[[4nal]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4nal' size='340' side='right'caption='[[4nal]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nal]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nal]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAL FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=H70:2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL'>H70</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w77|1w77]], [[2yc5|2yc5]], [[1ini|1ini]], [[4nai|4nai]], [[4nak|4nak]], [[4nan|4nan]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=H70:2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL'>H70</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At2g02500, ISPD, MCT, MECT, MEPCT, T8K22.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nal OCA], [https://pdbe.org/4nal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nal RCSB], [https://www.ebi.ac.uk/pdbsum/4nal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nal ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nal OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nal RCSB], [http://www.ebi.ac.uk/pdbsum/4nal PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/ISPD_ARATH ISPD_ARATH] Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.<ref>PMID:10841550</ref> <ref>PMID:12029484</ref> <ref>PMID:18236010</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.,Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Hoffken HW, Seet M, Eisenreich W, Knolker HJ, Fischer M, Bacher A, Groll M, Diederich F Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309557. PMID:24446431<ref>PMID:24446431</ref>
Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.,Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Hoffken HW, Seet M, Eisenreich W, Knolker HJ, Fischer M, Bacher A, Groll M, Diederich F Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309557. PMID:24446431<ref>PMID:24446431</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nal" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[MEP cytidylyltransferase 3D structures|MEP cytidylyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Arath]]
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[[Category: Large Structures]]
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[[Category: Bacher, A.]]
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[[Category: Bacher A]]
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[[Category: Diederich, F.]]
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[[Category: Diederich F]]
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[[Category: Eisenreich, W.]]
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[[Category: Eisenreich W]]
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[[Category: Fischer, M.]]
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[[Category: Fischer M]]
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[[Category: Groll, M.]]
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[[Category: Groll M]]
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[[Category: Hoffken, H W.]]
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[[Category: Hoffken HW]]
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[[Category: Illarionov, B.]]
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[[Category: Illarionov B]]
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[[Category: Knolker, H J.]]
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[[Category: Knolker H-J]]
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[[Category: Kunfermann, A.]]
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[[Category: Kunfermann A]]
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[[Category: Martin, R.]]
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[[Category: Martin R]]
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[[Category: Rottmann, M.]]
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[[Category: Rottmann M]]
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[[Category: Seet, M.]]
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[[Category: Seet M]]
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[[Category: Witschel, M.]]
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[[Category: Witschel M]]
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[[Category: Allosteric inhibition]]
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[[Category: Anti-infective]]
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[[Category: Drug discovery]]
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[[Category: Herbicide]]
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[[Category: Natural product]]
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[[Category: Pseudilin]]
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[[Category: Rossmann fold]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Arabidopsis thaliana IspD in complex with tribromodichloro-pseudilin

PDB ID 4nal

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