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4nb4

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==Pantothenamide-bound Pantothenate kinase from Staphylococcus aureus==
==Pantothenamide-bound Pantothenate kinase from Staphylococcus aureus==
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<StructureSection load='4nb4' size='340' side='right' caption='[[4nb4]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='4nb4' size='340' side='right'caption='[[4nb4]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nb4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NB4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nb4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NB4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SH3:N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE'>SH3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ne2|4ne2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SH3:N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE'>SH3</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CoaA, coaW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nb4 OCA], [https://pdbe.org/4nb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nb4 RCSB], [https://www.ebi.ac.uk/pdbsum/4nb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nb4 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nb4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nb4 RCSB], [http://www.ebi.ac.uk/pdbsum/4nb4 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/COAW_STAAS COAW_STAAS]] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16905099</ref>
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[https://www.uniprot.org/uniprot/COAW_STAAS COAW_STAAS] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16905099</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nb4" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Pantothenate kinase|Pantothenate kinase]]
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*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pantothenate kinase]]
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[[Category: Large Structures]]
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[[Category: Staar]]
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[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
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[[Category: Antoshchenko, T]]
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[[Category: Antoshchenko T]]
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[[Category: Hughes, S J]]
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[[Category: Hughes SJ]]
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[[Category: Park, H W]]
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[[Category: Park HW]]
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[[Category: Smil, D]]
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[[Category: Smil D]]
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[[Category: Protein-substrate complex]]
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[[Category: Transferase]]
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Current revision

Pantothenamide-bound Pantothenate kinase from Staphylococcus aureus

PDB ID 4nb4

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