4nyw

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(New page: '''Unreleased structure''' The entry 4nyw is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Rooney, T.P.C., Fedorov, O., Martin, S., Monteiro, O.P., Conway, S.J., Von D...)
Current revision (17:05, 20 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4nyw is ON HOLD
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==Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand==
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<StructureSection load='4nyw' size='340' side='right'caption='[[4nyw]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NYW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2O3:(3R)-N-[3-(3,4-DIHYDROQUINOLIN-1(2H)-YL)PROPYL]-3-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOXALINE-5-CARBOXAMIDE'>2O3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyw OCA], [https://pdbe.org/4nyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nyw RCSB], [https://www.ebi.ac.uk/pdbsum/4nyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nyw ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
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Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Rooney, T.P.C., Fedorov, O., Martin, S., Monteiro, O.P., Conway, S.J., Von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==See Also==
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*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
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Description: Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Brennan P]]
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[[Category: Conway SJ]]
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[[Category: Edwards AM]]
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[[Category: Fedorov O]]
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[[Category: Felletar I]]
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[[Category: Filippakopoulos P]]
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[[Category: Knapp S]]
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[[Category: Martin S]]
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[[Category: Monteiro OP]]
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[[Category: Picaud S]]
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[[Category: Rooney TPC]]
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[[Category: Von Delft F]]

Current revision

Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand

PDB ID 4nyw

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