This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4o46

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:06, 20 September 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
 +
==14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228==
==14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228==
-
<StructureSection load='4o46' size='340' side='right' caption='[[4o46]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+
<StructureSection load='4o46' size='340' side='right'caption='[[4o46]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
[[4o46]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O46 OCA]. <br>
+
<table><tr><td colspan='2'>[[4o46]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O46 FirstGlance]. <br>
-
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o46 OCA], [https://pdbe.org/4o46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o46 RCSB], [https://www.ebi.ac.uk/pdbsum/4o46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o46 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/1433G_HUMAN 1433G_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:16511572</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Pathogens can interfere with vital biological processes of their host by mimicking host proteins. The NS1 protein of the influenza A H3N2 subtype possesses a histone H3K4-like sequence at its carboxyl terminus and has been reported to use this mimic to hijack host proteins. However, this mimic lacks a free N-terminus that is essential for binding to many known H3K4 readers. Here we show that the double chromodomains of CHD1 adopt an 'open pocket' to interact with the free N-terminal amine of H3K4, and the open pocket permits the NS1 mimic to bind in a distinct conformation. We also explored the possibility that NS1 hijacks other cellular proteins and found that the NS1 mimic has access to only a subset of chromatin-associated factors, such as WDR5. Moreover, methylation of the NS1 mimic can not be reversed by the H3K4 demethylase LSD1. Overall, we thus conclude that the NS1 mimic is an imperfect histone mimic.
 +
 
 +
Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.,Qin S, Liu Y, Tempel W, Eram MS, Bian C, Liu K, Senisterra G, Crombet L, Vedadi M, Min J Nat Commun. 2014 May 23;5:3952. doi: 10.1038/ncomms4952. PMID:24853335<ref>PMID:24853335</ref>
 +
 
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4o46" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Homo sapiens]]
-
[[Category: Bountra, C.]]
+
[[Category: Influenza A virus H3N2]]
-
[[Category: Edwards, A M.]]
+
[[Category: Large Structures]]
-
[[Category: Liu, Y.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Min, J.]]
+
[[Category: Bountra C]]
-
[[Category: Qin, S.]]
+
[[Category: Edwards AM]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Liu Y]]
-
[[Category: Tempel, W.]]
+
[[Category: Min J]]
-
[[Category: Influenza]]
+
[[Category: Qin S]]
-
[[Category: Sgc]]
+
[[Category: Tempel W]]
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Viral protein]]
+

Current revision

14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228

PDB ID 4o46

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4o46"
Personal tools