4o4h

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==Tubulin-Laulimalide complex==
==Tubulin-Laulimalide complex==
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<StructureSection load='4o4h' size='340' side='right' caption='[[4o4h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4o4h' size='340' side='right'caption='[[4o4h]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o4h]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o4h]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4H FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o4i|4o4i]], [[4o4j|4o4j]], [[4o4l|4o4l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LLM:LAULIMALIDE'>LLM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o4h RCSB], [http://www.ebi.ac.uk/pdbsum/4o4h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4h OCA], [https://pdbe.org/4o4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4h RCSB], [https://www.ebi.ac.uk/pdbsum/4o4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4h ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural basis of microtubule stabilization by laulimalide and peloruside a.,Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Diaz JF, Steinmetz MO Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749., Epub 2014 Jan 27. PMID:24470331<ref>PMID:24470331</ref>
Structural basis of microtubule stabilization by laulimalide and peloruside a.,Prota AE, Bargsten K, Northcote PT, Marsh M, Altmann KH, Miller JH, Diaz JF, Steinmetz MO Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1621-5. doi: 10.1002/anie.201307749., Epub 2014 Jan 27. PMID:24470331<ref>PMID:24470331</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4o4h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Buffalo rat]]
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[[Category: Gallus gallus]]
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[[Category: Chick]]
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[[Category: Large Structures]]
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[[Category: Altmann, K H.]]
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[[Category: Rattus norvegicus]]
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[[Category: Bargsten, K.]]
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[[Category: Altmann KH]]
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[[Category: Diaz, J F.]]
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[[Category: Bargsten K]]
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[[Category: Marsh, M.]]
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[[Category: Diaz JF]]
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[[Category: Miller, J H.]]
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[[Category: Marsh M]]
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[[Category: Northcote, P T.]]
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[[Category: Miller JH]]
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[[Category: Prota, A E.]]
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[[Category: Northcote PT]]
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[[Category: Steinmetz, M O.]]
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[[Category: Prota AE]]
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[[Category: Alpha-tubulin]]
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[[Category: Steinmetz MO]]
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[[Category: Beta-tubulin]]
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[[Category: Cell cycle]]
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[[Category: Cell cycle-inhibitor complex]]
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[[Category: Cytoskeleton]]
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[[Category: Gtpase]]
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[[Category: Laulimalide]]
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[[Category: Ligase]]
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[[Category: Microtubule]]
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[[Category: Stathmin]]
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[[Category: Tubulin fold]]
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Current revision

Tubulin-Laulimalide complex

PDB ID 4o4h

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