4o4y

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==Crystal structure of the anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide==
==Crystal structure of the anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide==
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<StructureSection load='4o4y' size='340' side='right' caption='[[4o4y]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='4o4y' size='340' side='right'caption='[[4o4y]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o4y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O4Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o4y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O4Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ma3|4ma3]], [[4o51|4o51]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4y OCA], [https://pdbe.org/4o4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o4y RCSB], [https://www.ebi.ac.uk/pdbsum/4o4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o4y OCA], [http://pdbe.org/4o4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o4y RCSB], [http://www.ebi.ac.uk/pdbsum/4o4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o4y ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: European rabbit]]
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[[Category: Homo sapiens]]
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[[Category: Gilliland, G L]]
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[[Category: Large Structures]]
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[[Category: Luo, J]]
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[[Category: Oryctolagus cuniculus]]
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[[Category: Malia, T J]]
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[[Category: Gilliland GL]]
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[[Category: Teplyakov, A]]
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[[Category: Luo J]]
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[[Category: Antibody]]
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[[Category: Malia TJ]]
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[[Category: Hinge]]
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[[Category: Teplyakov A]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin fold]]
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Current revision

Crystal structure of the anti-hinge rabbit antibody 2095-2 in complex with IDES hinge peptide

PDB ID 4o4y

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