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4o75

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==Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB==
==Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB==
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<StructureSection load='4o75' size='340' side='right' caption='[[4o75]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4o75' size='340' side='right'caption='[[4o75]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o75]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O75 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o75]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O75 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2RC:[6-({5-FLUORO-2-[(3,4,5-TRIMETHOXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-PYRIDO[3,2-B][1,4]OXAZIN-4-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2RC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o70|4o70]], [[4o71|4o71]], [[4o72|4o72]], [[4o73|4o73]], [[4o74|4o74]], [[4o76|4o76]], [[4o77|4o77]], [[4o78|4o78]], [[4o7a|4o7a]], [[4o7b|4o7b]], [[4o7c|4o7c]], [[4o7e|4o7e]], [[4o7f|4o7f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2RC:[6-({5-FLUORO-2-[(3,4,5-TRIMETHOXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-PYRIDO[3,2-B][1,4]OXAZIN-4-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2RC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o75 OCA], [https://pdbe.org/4o75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o75 RCSB], [https://www.ebi.ac.uk/pdbsum/4o75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o75 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o75 RCSB], [http://www.ebi.ac.uk/pdbsum/4o75 PDBsum]</span></td></tr>
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</table>
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<table>
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== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.,Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E ACS Chem Biol. 2014 Mar 13. PMID:24568369<ref>PMID:24568369</ref>
Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.,Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E ACS Chem Biol. 2014 Mar 13. PMID:24568369<ref>PMID:24568369</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4o75" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Ember, S W.]]
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[[Category: Large Structures]]
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[[Category: Schonbrunn, E.]]
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[[Category: Ember SW]]
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[[Category: Watts, C.]]
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[[Category: Schonbrunn E]]
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[[Category: Zhu, J Y.]]
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[[Category: Watts C]]
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[[Category: Bromodomain]]
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[[Category: Zhu J-Y]]
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[[Category: Cap]]
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[[Category: Cell cycle]]
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[[Category: Hunk1]]
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[[Category: Inhibitor]]
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[[Category: Mcap]]
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[[Category: Mitotic chromosome associated protein]]
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[[Category: Protein binding-inhibitor complex]]
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[[Category: Transcription-inhibitor complex]]
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Current revision

Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB

PDB ID 4o75

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