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4oar

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==Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT==
==Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT==
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<StructureSection load='4oar' size='340' side='right' caption='[[4oar]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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<StructureSection load='4oar' size='340' side='right'caption='[[4oar]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oar]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OAR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oar]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OAR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2S0:[(8S,11R,13S,14S,17R)-17-ACETYL-11-[4-(DIMETHYLAMINO)PHENYL]-13-METHYL-3-OXO-1,2,6,7,8,11,12,14,15,16-DECAHYDROCYCLOPENTA[A]PHENANTHREN-17-YL]+ACETATE'>2S0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oar OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oar RCSB], [http://www.ebi.ac.uk/pdbsum/4oar PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2S0:[(8S,11R,13S,14S,17R)-17-ACETYL-11-[4-(DIMETHYLAMINO)PHENYL]-13-METHYL-3-OXO-1,2,6,7,8,11,12,14,15,16-DECAHYDROCYCLOPENTA[A]PHENANTHREN-17-YL]+ACETATE'>2S0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oar OCA], [https://pdbe.org/4oar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oar RCSB], [https://www.ebi.ac.uk/pdbsum/4oar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oar ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4oar" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
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*[[Progesterone receptor|Progesterone receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fagart, J.]]
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[[Category: Homo sapiens]]
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[[Category: Fay, M R.]]
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[[Category: Large Structures]]
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[[Category: Gainer, E.]]
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[[Category: Fagart J]]
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[[Category: Petit-Topin, I.]]
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[[Category: Fay MR]]
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[[Category: Rafestin-Oblin, M E.]]
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[[Category: Gainer E]]
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[[Category: Resche-Rigon, M.]]
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[[Category: Petit-Topin I]]
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[[Category: Ulmann, A.]]
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[[Category: Rafestin-Oblin M-E]]
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[[Category: Contraception]]
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[[Category: Resche-Rigon M]]
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[[Category: Nuclear receptor]]
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[[Category: Ulmann A]]
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[[Category: Progesterone receptor]]
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[[Category: Steroid receptor]]
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[[Category: Transcription factor]]
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[[Category: Transcription-peptide complex]]
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[[Category: Women health]]
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Current revision

Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT

PDB ID 4oar

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