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4ocp

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==N-acetylhexosamine 1-phosphate kinase in complex with GlcNAc-1-phosphate and ADP==
==N-acetylhexosamine 1-phosphate kinase in complex with GlcNAc-1-phosphate and ADP==
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<StructureSection load='4ocp' size='340' side='right' caption='[[4ocp]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='4ocp' size='340' side='right'caption='[[4ocp]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ocp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OCP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ocp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bifidobacterium_longum Bifidobacterium longum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OCP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GN1:2-(ACETYLAMINO)-2-DEOXY-1-O-PHOSPHONO-ALPHA-D-GLUCOPYRANOSE'>GN1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.938&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GN1:2-(ACETYLAMINO)-2-DEOXY-1-O-PHOSPHONO-ALPHA-D-GLUCOPYRANOSE'>GN1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ocj|4ocj]], [[4ock|4ock]], [[4oco|4oco]], [[4ocq|4ocq]], [[4ocu|4ocu]], [[4ocv|4ocv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ocp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ocp OCA], [https://pdbe.org/4ocp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ocp RCSB], [https://www.ebi.ac.uk/pdbsum/4ocp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ocp ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylhexosamine_1-kinase N-acetylhexosamine 1-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.162 2.7.1.162] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ocp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ocp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ocp RCSB], [http://www.ebi.ac.uk/pdbsum/4ocp PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NAHK_BIFL2 NAHK_BIFL2] Phosphorylates both N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) at similar rates. Involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria. Also accepts GTP and ITP as phosphate donors. In vitro, can phosphorylate several GlcNAc and GalNAc derivatives.<ref>PMID:17720833</ref> <ref>PMID:19436918</ref> <ref>PMID:19683921</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ocp" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: N-acetylhexosamine 1-kinase]]
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[[Category: Bifidobacterium longum]]
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[[Category: Chang, C Y]]
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[[Category: Large Structures]]
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[[Category: Li, T L]]
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[[Category: Chang CY]]
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[[Category: Liu, Y C]]
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[[Category: Li TL]]
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[[Category: Lyu, S Y]]
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[[Category: Liu YC]]
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[[Category: Wang, K C]]
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[[Category: Lyu SY]]
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[[Category: Wu, C J]]
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[[Category: Wang KC]]
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[[Category: Kinase]]
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[[Category: Wu CJ]]
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[[Category: Transferase]]
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Current revision

N-acetylhexosamine 1-phosphate kinase in complex with GlcNAc-1-phosphate and ADP

PDB ID 4ocp

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