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4od0

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==Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea==
==Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea==
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<StructureSection load='4od0' size='340' side='right' caption='[[4od0]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
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<StructureSection load='4od0' size='340' side='right'caption='[[4od0]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4od0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OD0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4od0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OD0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2RV:1-(1-PROPANOYLPIPERIDIN-4-YL)-3-[4-(TRIFLUOROMETHOXY)PHENYL]UREA'>2RV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ocz|4ocz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2RV:1-(1-PROPANOYLPIPERIDIN-4-YL)-3-[4-(TRIFLUOROMETHOXY)PHENYL]UREA'>2RV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4od0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4od0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4od0 RCSB], [http://www.ebi.ac.uk/pdbsum/4od0 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4od0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4od0 OCA], [https://pdbe.org/4od0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4od0 RCSB], [https://www.ebi.ac.uk/pdbsum/4od0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4od0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN]] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
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[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4od0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dong, H]]
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[[Category: Homo sapiens]]
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[[Category: Eldin, M L]]
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[[Category: Large Structures]]
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[[Category: Fu, S H]]
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[[Category: Dong H]]
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[[Category: Hammock, B D]]
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[[Category: Eldin ML]]
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[[Category: Lee, K S.S]]
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[[Category: Fu SH]]
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[[Category: Liu, J]]
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[[Category: Hammock BD]]
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[[Category: Mara, A A]]
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[[Category: Lee KSS]]
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[[Category: Mate, C]]
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[[Category: Liu J]]
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[[Category: Morisseau, C]]
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[[Category: Mara AA]]
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[[Category: Newcomer, M E]]
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[[Category: Mate C]]
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[[Category: Nguyen, L]]
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[[Category: Morisseau C]]
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[[Category: Pakhomova, S]]
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[[Category: Newcomer ME]]
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[[Category: Ulu, A]]
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[[Category: Nguyen L]]
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[[Category: Wagner, K M]]
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[[Category: Pakhomova S]]
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[[Category: Wang, P]]
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[[Category: Ulu A]]
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[[Category: Wullf, H]]
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[[Category: Wagner KM]]
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[[Category: Yang, J]]
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[[Category: Wang P]]
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[[Category: Zeldin, D C]]
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[[Category: Wullf H]]
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[[Category: Domain-swapped dimer]]
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[[Category: Yang J]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Zeldin DC]]

Current revision

Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea

PDB ID 4od0

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