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4oj8

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==Crystal structure of carbapenem synthase in complex with (3S,5S)-carbapenam==
==Crystal structure of carbapenem synthase in complex with (3S,5S)-carbapenam==
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<StructureSection load='4oj8' size='340' side='right' caption='[[4oj8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4oj8' size='340' side='right'caption='[[4oj8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oj8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Erwinia_carotovora_carotovora Erwinia carotovora carotovora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OJ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oj8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pectobacterium_carotovorum_subsp._carotovorum Pectobacterium carotovorum subsp. carotovorum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OJ8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2TQ:(2S,5S)-7-OXO-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC+ACID'>2TQ</scene>, <scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">carC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555 Erwinia carotovora carotovora])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2TQ:(2S,5S)-7-OXO-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC+ACID'>2TQ</scene>, <scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(5R)-carbapenem-3-carboxylate_synthase (5R)-carbapenem-3-carboxylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.20.3 1.14.20.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oj8 OCA], [https://pdbe.org/4oj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oj8 RCSB], [https://www.ebi.ac.uk/pdbsum/4oj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oj8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4oj8 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CARC_PECCC CARC_PECCC]] Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent conversion of (3S,5S)-carbapenam to (5R)-carbapenem, an essential step in carbapenem antibiotic biosynthesis.<ref>PMID:9402024</ref> <ref>PMID:12848554</ref> <ref>PMID:15174175</ref> <ref>PMID:12611886</ref>
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[https://www.uniprot.org/uniprot/CARC_PECCC CARC_PECCC] Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent conversion of (3S,5S)-carbapenam to (5R)-carbapenem, an essential step in carbapenem antibiotic biosynthesis.<ref>PMID:9402024</ref> <ref>PMID:12848554</ref> <ref>PMID:15174175</ref> <ref>PMID:12611886</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4oj8" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Erwinia carotovora carotovora]]
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[[Category: Large Structures]]
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[[Category: Boal, A K]]
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[[Category: Pectobacterium carotovorum subsp. carotovorum]]
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[[Category: Rosenzweig, A C]]
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[[Category: Boal AK]]
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[[Category: 2-oxoglutaric acid]]
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[[Category: Rosenzweig AC]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: Carbapenam]]
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[[Category: Iron]]
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[[Category: Oxidoreductase]]
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[[Category: Oxygenase]]
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Current revision

Crystal structure of carbapenem synthase in complex with (3S,5S)-carbapenam

PDB ID 4oj8

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