This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4prr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:21, 20 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A==
==Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A==
-
<StructureSection load='4prr' size='340' side='right' caption='[[4prr]], [[Resolution|resolution]] 1.01&Aring;' scene=''>
+
<StructureSection load='4prr' size='340' side='right'caption='[[4prr]], [[Resolution|resolution]] 1.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4prr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PRR FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4prr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PRR FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2W9:3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC+ACID'>2W9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.01&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ikg|2ikg]], [[2ikh|2ikh]], [[3dn5|3dn5]], [[4nkc|4nkc]], [[4pr4|4pr4]], [[4prt|4prt]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W9:3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC+ACID'>2W9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4prr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4prr OCA], [https://pdbe.org/4prr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4prr RCSB], [https://www.ebi.ac.uk/pdbsum/4prr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4prr ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4prr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4prr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4prr RCSB], [http://www.ebi.ac.uk/pdbsum/4prr PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
+
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
 +
 
 +
==See Also==
 +
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Aldehyde reductase]]
+
[[Category: Homo sapiens]]
-
[[Category: Heine, A]]
+
[[Category: Large Structures]]
-
[[Category: Klebe, G]]
+
[[Category: Heine A]]
-
[[Category: Rechlin, C]]
+
[[Category: Klebe G]]
-
[[Category: Oxidoreductase]]
+
[[Category: Rechlin C]]
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+
-
[[Category: Tim barrel]]
+

Current revision

Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A

PDB ID 4prr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools