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4pth

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<StructureSection load='4pth' size='340' side='right'caption='[[4pth]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
<StructureSection load='4pth' size='340' side='right'caption='[[4pth]], [[Resolution|resolution]] 0.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecodh Ecodh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PTH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._DH10B Escherichia coli str. K-12 substr. DH10B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PTH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.85&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pss|4pss]], [[4psy|4psy]], [[4ptj|4ptj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pth OCA], [https://pdbe.org/4pth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pth RCSB], [https://www.ebi.ac.uk/pdbsum/4pth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pth ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, ECDH10B_0049 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=316385 ECODH])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pth OCA], [http://pdbe.org/4pth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pth RCSB], [http://www.ebi.ac.uk/pdbsum/4pth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pth ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/B1XC49_ECODH B1XC49_ECODH]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Escherichia coli str. K-12 substr. DH10B]]
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[[Category: Ecodh]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bedem, H van den]]
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[[Category: Fraser JS]]
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[[Category: Fraser, J S]]
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[[Category: Keedy DA]]
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[[Category: Keedy, D A]]
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[[Category: Petsko GA]]
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[[Category: Petsko, G A]]
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[[Category: Ringe D]]
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[[Category: Ringe, D]]
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[[Category: Sivak DA]]
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[[Category: Sivak, D A]]
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[[Category: Wilson MA]]
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[[Category: Wilson, M A]]
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[[Category: Van den Bedem H]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

Ensemble model for Escherichia coli dihydrofolate reductase at 100K

PDB ID 4pth

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