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4qdh

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==Crystal Structure of the C-terminal Domain of Mouse TLR9==
==Crystal Structure of the C-terminal Domain of Mouse TLR9==
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<StructureSection load='4qdh' size='340' side='right' caption='[[4qdh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4qdh' size='340' side='right'caption='[[4qdh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qdh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QDH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qdh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QDH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.399&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr9, VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qdh OCA], [http://pdbe.org/4qdh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qdh RCSB], [http://www.ebi.ac.uk/pdbsum/4qdh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qdh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qdh OCA], [https://pdbe.org/4qdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qdh RCSB], [https://www.ebi.ac.uk/pdbsum/4qdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qdh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU] [https://www.uniprot.org/uniprot/TLR9_MOUSE TLR9_MOUSE] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection.<ref>PMID:14993594</ref> <ref>PMID:17474149</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4qdh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4qdh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bdellostoma burgeri]]
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[[Category: Eptatretus burgeri]]
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[[Category: Collins, B C]]
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[[Category: Large Structures]]
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[[Category: Wilson, I A]]
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[[Category: Mus musculus]]
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[[Category: Glycosylation]]
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[[Category: Collins BC]]
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[[Category: Immune system]]
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[[Category: Wilson IA]]

Current revision

Crystal Structure of the C-terminal Domain of Mouse TLR9

PDB ID 4qdh

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