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4qim

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==Structure of the human smoothened receptor in complex with ANTA XV==
==Structure of the human smoothened receptor in complex with ANTA XV==
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<StructureSection load='4qim' size='340' side='right' caption='[[4qim]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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<StructureSection load='4qim' size='340' side='right'caption='[[4qim]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qim]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QIM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QIM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8T:2-{6-[4-(4-BENZYLPHTHALAZIN-1-YL)PIPERAZIN-1-YL]PYRIDIN-3-YL}PROPAN-2-OL'>A8T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o9r|4o9r]], [[4qin|4qin]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8T:2-{6-[4-(4-BENZYLPHTHALAZIN-1-YL)PIPERAZIN-1-YL]PYRIDIN-3-YL}PROPAN-2-OL'>A8T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qim OCA], [http://pdbe.org/4qim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qim RCSB], [http://www.ebi.ac.uk/pdbsum/4qim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qim ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qim OCA], [https://pdbe.org/4qim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qim RCSB], [https://www.ebi.ac.uk/pdbsum/4qim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qim ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Caron, M G]]
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[[Category: Homo sapiens]]
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[[Category: Cherezov, V]]
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[[Category: Large Structures]]
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[[Category: Evron, T]]
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[[Category: Caron MG]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Cherezov V]]
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[[Category: Han, G W]]
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[[Category: Evron T]]
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[[Category: Huang, X P]]
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[[Category: Han GW]]
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[[Category: Hufeisen, S J]]
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[[Category: Huang X-P]]
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[[Category: Katritch, V]]
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[[Category: Hufeisen SJ]]
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[[Category: Mangano, T J]]
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[[Category: Katritch V]]
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[[Category: Roth, B L]]
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[[Category: Mangano TJ]]
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[[Category: Stevens, R C]]
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[[Category: Roth BL]]
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[[Category: Urban, D J]]
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[[Category: Stevens RC]]
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[[Category: Vardy, E]]
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[[Category: Urban DJ]]
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[[Category: Wang, C]]
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[[Category: Vardy E]]
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[[Category: Wu, H]]
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[[Category: Wang C]]
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[[Category: Antitumor agent]]
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[[Category: Wu H]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Human smoothened receptor]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Structure of the human smoothened receptor in complex with ANTA XV

PDB ID 4qim

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