This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4r68

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:44, 20 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Lactate Dehydrogenase in complex with inhibitor compound 31==
==Lactate Dehydrogenase in complex with inhibitor compound 31==
-
<StructureSection load='4r68' size='340' side='right' caption='[[4r68]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
+
<StructureSection load='4r68' size='340' side='right'caption='[[4r68]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R68 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4r68]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R68 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.112&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r69|4r69]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W31:(1S)-1-PHENYLETHYL+(4-CHLORO-3-{[(4S)-4-(2,6-DICHLOROPHENYL)-2-HYDROXY-6-OXOCYCLOHEX-1-EN-1-YL]SULFANYL}PHENYL)ACETATE'>W31</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [https://pdbe.org/4r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [https://www.ebi.ac.uk/pdbsum/4r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r68 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r68 RCSB], [http://www.ebi.ac.uk/pdbsum/4r68 PDBsum]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
+
[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 20:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4r68" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: L-lactate dehydrogenase]]
+
[[Category: Homo sapiens]]
-
[[Category: Eigenbrot, C]]
+
[[Category: Large Structures]]
-
[[Category: Ultsch, M]]
+
[[Category: Eigenbrot C]]
-
[[Category: Nicotinamide adenine dinucleaotide]]
+
[[Category: Ultsch M]]
-
[[Category: Oxidoreductase]]
+

Current revision

Lactate Dehydrogenase in complex with inhibitor compound 31

PDB ID 4r68

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4r68"
Personal tools