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4ram

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(New page: ==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G== <StructureSection load='4ram' size='340' side='right' caption='4ram, [[Re...)
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==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G==
==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G==
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<StructureSection load='4ram' size='340' side='right' caption='[[4ram]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4ram' size='340' side='right'caption='[[4ram]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ram]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ram]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.495&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4h0d|4h0d]], [[4hky|4hky]], [[4hl1|4hl1]], [[4gyu|4gyu]], [[4hl2|4hl2]], [[4raw|4raw]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ram FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ram OCA], [https://pdbe.org/4ram PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ram RCSB], [https://www.ebi.ac.uk/pdbsum/4ram PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ram ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ram FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ram OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ram RCSB], [http://www.ebi.ac.uk/pdbsum/4ram PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
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[[Category: Babnigg, G.]]
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[[Category: Large Structures]]
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[[Category: Jedrzejczak, R.]]
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[[Category: Babnigg G]]
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[[Category: Joachimiak, A.]]
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[[Category: Jedrzejczak R]]
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[[Category: Kim, Y.]]
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[[Category: Joachimiak A]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Kim Y]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
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[[Category: Sacchettini J]]
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[[Category: Sacchettini, J.]]
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[[Category: Tesar C]]
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[[Category: Tesar, C.]]
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[[Category: Alpha-beta-beta-alpha sandwich]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-antibiotic complex]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Mtbi]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]
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Current revision

Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G

PDB ID 4ram

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