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4rcj

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==Crystal structure of YTHDF1 YTH domain in complex with 5mer m6A RNA==
==Crystal structure of YTHDF1 YTH domain in complex with 5mer m6A RNA==
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<StructureSection load='4rcj' size='340' side='right' caption='[[4rcj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='4rcj' size='340' side='right'caption='[[4rcj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rcj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RCJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rcj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RCJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rci|4rci]], [[4rcm|4rcm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rcj OCA], [https://pdbe.org/4rcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rcj RCSB], [https://www.ebi.ac.uk/pdbsum/4rcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rcj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rcj RCSB], [http://www.ebi.ac.uk/pdbsum/4rcj PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YTHD1_HUMAN YTHD1_HUMAN]] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.<ref>PMID:24284625</ref>
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[https://www.uniprot.org/uniprot/YTHD1_HUMAN YTHD1_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability.<ref>PMID:24284625</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4rcj" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Edwards, A M]]
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[[Category: Synthetic construct]]
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[[Category: Min, J]]
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[[Category: Arrowsmith CH]]
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[[Category: Structural genomic]]
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[[Category: Bountra C]]
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[[Category: Tempel, W]]
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[[Category: Edwards AM]]
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[[Category: Xu, C]]
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[[Category: Min J]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Tempel W]]
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[[Category: Sgc]]
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[[Category: Xu C]]

Current revision

Crystal structure of YTHDF1 YTH domain in complex with 5mer m6A RNA

PDB ID 4rcj

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