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4re5

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==Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor==
==Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor==
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<StructureSection load='4re5' size='340' side='right' caption='[[4re5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4re5' size='340' side='right'caption='[[4re5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4re5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RE5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4re5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix_K1 Aeropyrum pernix K1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RE5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=Y3A:N-[(BENZYLOXY)CARBONYL]GLYCYL-N-[(2S,3R)-4-CHLORO-3-HYDROXY-1-PHENYLBUTAN-2-YL]GLYCINAMIDE'>Y3A</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4re6|4re6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=Y3A:N-[(BENZYLOXY)CARBONYL]GLYCYL-N-[(2S,3R)-4-CHLORO-3-HYDROXY-1-PHENYLBUTAN-2-YL]GLYCINAMIDE'>Y3A</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acylaminoacyl-peptidase Acylaminoacyl-peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.1 3.4.19.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4re5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4re5 OCA], [https://pdbe.org/4re5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4re5 RCSB], [https://www.ebi.ac.uk/pdbsum/4re5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4re5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4re5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4re5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4re5 RCSB], [http://www.ebi.ac.uk/pdbsum/4re5 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE]] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
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[https://www.uniprot.org/uniprot/APEH_AERPE APEH_AERPE] This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4re5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acylaminoacyl peptidase 3D structures|Acylaminoacyl peptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acylaminoacyl-peptidase]]
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[[Category: Aeropyrum pernix K1]]
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[[Category: Harmat, V]]
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[[Category: Large Structures]]
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[[Category: Menyhard, D K]]
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[[Category: Harmat V]]
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[[Category: Orgovan, Z]]
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[[Category: Menyhard DK]]
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[[Category: Szamosi, I]]
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[[Category: Orgovan Z]]
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[[Category: Szeltner, Z]]
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[[Category: Szamosi I]]
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[[Category: Alpha-beta-hydrolase fold]]
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[[Category: Szeltner Z]]
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[[Category: Beta-propeller]]
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[[Category: Chloromethyl-ketone inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor

PDB ID 4re5

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