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4rle

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==Crystal structure of the c-di-AMP binding PII-like protein DarA==
==Crystal structure of the c-di-AMP binding PII-like protein DarA==
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<StructureSection load='4rle' size='340' side='right' caption='[[4rle]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='4rle' size='340' side='right'caption='[[4rle]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rle]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rle]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RLE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rle OCA], [http://pdbe.org/4rle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rle RCSB], [http://www.ebi.ac.uk/pdbsum/4rle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rle ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rle OCA], [https://pdbe.org/4rle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rle RCSB], [https://www.ebi.ac.uk/pdbsum/4rle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rle ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DARA_BACSU DARA_BACSU] Binds cyclic di-AMP (c-di-AMP) and is probably involved in c-di-AMP-mediated signaling pathways. In vitro, can also bind cyclic GMP-AMP (3'3'-cGAMP), with lower affinity, but not c-di-GMP or 2'3'-cGAMP.<ref>PMID:25433025</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dickmanns, A]]
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Ficner, R]]
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[[Category: Large Structures]]
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[[Category: Neumann, P]]
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[[Category: Dickmanns A]]
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[[Category: Cdiamp]]
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[[Category: Ficner R]]
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[[Category: Pii-like]]
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[[Category: Neumann P]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of the c-di-AMP binding PII-like protein DarA

PDB ID 4rle

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