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4rut

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==crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid==
==crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid==
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<StructureSection load='4rut' size='340' side='right' caption='[[4rut]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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<StructureSection load='4rut' size='340' side='right'caption='[[4rut]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rut]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rut]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=LM8:(5Z,8Z,11Z,13S,14Z)-13-METHYLICOSA-5,8,11,14-TETRAENOIC+ACID'>LM8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=LM8:(5Z,8Z,11Z,13S,14Z)-13-METHYLICOSA-5,8,11,14-TETRAENOIC+ACID'>LM8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rut RCSB], [http://www.ebi.ac.uk/pdbsum/4rut PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rut OCA], [https://pdbe.org/4rut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rut RCSB], [https://www.ebi.ac.uk/pdbsum/4rut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rut ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
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[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4rut" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Prostaglandin-endoperoxide synthase]]
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[[Category: Large Structures]]
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[[Category: Banerjee, S]]
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[[Category: Mus musculus]]
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[[Category: Kudalkar, S N]]
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[[Category: Banerjee S]]
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[[Category: Makriyannis, A]]
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[[Category: Kudalkar SN]]
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[[Category: Marnett, L J]]
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[[Category: Makriyannis A]]
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[[Category: Nikas, S P]]
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[[Category: Marnett LJ]]
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[[Category: Xu, S]]
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[[Category: Nikas SP]]
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[[Category: Fatty acid analog]]
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[[Category: Xu S]]
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[[Category: Glycosylation]]
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[[Category: Membrane]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-ligand complex]]
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Current revision

crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid

PDB ID 4rut

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