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4thi

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==THIAMINASE I FROM BACILLUS THIAMINOLYTICUS WITH COVALENTLY BOUND 4-AMINO-2,5-DIMETHYLPYRIMIDINE==
==THIAMINASE I FROM BACILLUS THIAMINOLYTICUS WITH COVALENTLY BOUND 4-AMINO-2,5-DIMETHYLPYRIMIDINE==
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<StructureSection load='4thi' size='340' side='right' caption='[[4thi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4thi' size='340' side='right'caption='[[4thi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4thi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4THI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4THI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4thi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4THI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4THI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PYD:2,5-DIMETHYL-PYRIMIDIN-4-YLAMINE'>PYD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine_pyridinylase Thiamine pyridinylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.2 2.5.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYD:2,5-DIMETHYL-PYRIMIDIN-4-YLAMINE'>PYD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4thi OCA], [http://pdbe.org/4thi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4thi RCSB], [http://www.ebi.ac.uk/pdbsum/4thi PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4thi OCA], [https://pdbe.org/4thi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4thi RCSB], [https://www.ebi.ac.uk/pdbsum/4thi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4thi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THI1_PANTH THI1_PANTH]] Degrades thiamine by replacing its thiazole moiety with a wide range of nucleophiles.
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[https://www.uniprot.org/uniprot/THI1_PANTH THI1_PANTH] Degrades thiamine by replacing its thiazole moiety with a wide range of nucleophiles.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/th/4thi_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/th/4thi_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 4thi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4thi" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thiaminase|Thiaminase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus globigii migula 1900]]
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[[Category: Bacillus subtilis]]
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[[Category: Thiamine pyridinylase]]
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[[Category: Large Structures]]
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[[Category: Begley, T P]]
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[[Category: Begley TP]]
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[[Category: Campobasso, N]]
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[[Category: Campobasso N]]
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[[Category: Ealick, S E]]
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[[Category: Ealick SE]]
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[[Category: Thiamin degradation]]
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[[Category: Transferase]]
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Current revision

THIAMINASE I FROM BACILLUS THIAMINOLYTICUS WITH COVALENTLY BOUND 4-AMINO-2,5-DIMETHYLPYRIMIDINE

PDB ID 4thi

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