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6s8m

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==S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state==
==S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state==
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<StructureSection load='6s8m' size='340' side='right'caption='[[6s8m]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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<SX load='6s8m' size='340' side='right' viewer='molstar' caption='[[6s8m]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6s8m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6s8m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5mlv 5mlv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S8M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EPB:7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE'>EPB</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mlv|5mlv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EPB:7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE'>EPB</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cut7, SPAC25G10.07c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356]), nda3, alp12, SPBC26H8.07c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356]), nda2, SPBC16A3.15c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8m OCA], [https://pdbe.org/6s8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s8m RCSB], [https://www.ebi.ac.uk/pdbsum/6s8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8m ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8m OCA], [http://pdbe.org/6s8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8m RCSB], [http://www.ebi.ac.uk/pdbsum/6s8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8m ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CUT7_SCHPO CUT7_SCHPO]] Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation. [[http://www.uniprot.org/uniprot/TBA1_SCHPO TBA1_SCHPO]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB_SCHPO TBB_SCHPO]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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[https://www.uniprot.org/uniprot/CUT7_SCHPO CUT7_SCHPO] Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Cbs 356]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Loeffelholz, O von]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Moores, C A]]
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[[Category: Moores CA]]
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[[Category: Cut7 motor domain]]
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[[Category: Von Loeffelholz O]]
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[[Category: Kinesin-5]]
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[[Category: Microtubule]]
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[[Category: Motor protein]]
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[[Category: S. pombe]]
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Current revision

S. pombe microtubule decorated with Cut7 motor domain in the AMPPNP state

6s8m, resolution 4.50Å

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