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2zwh

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{{Seed}}
 
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[[Image:2zwh.png|left|200px]]
 
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==Model for the F-actin structure==
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The line below this paragraph, containing "STRUCTURE_2zwh", creates the "Structure Box" on the page.
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<StructureSection load='2zwh' size='340' side='right'caption='[[2zwh]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZWH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Fiber diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
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{{STRUCTURE_2zwh| PDB=2zwh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zwh OCA], [https://pdbe.org/2zwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zwh RCSB], [https://www.ebi.ac.uk/pdbsum/2zwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zwh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Actin plays crucial parts in cell motility through a dynamic process driven by polymerization and depolymerization, that is, the globular (G) to fibrous (F) actin transition. Although our knowledge about the actin-based cellular functions and the molecules that regulate the G- to F-actin transition is growing, the structural aspects of the transition remain enigmatic. We created a model of F-actin using X-ray fibre diffraction intensities obtained from well oriented sols of rabbit skeletal muscle F-actin to 3.3 A in the radial direction and 5.6 A along the equator. Here we show that the G- to F-actin conformational transition is a simple relative rotation of the two major domains by about 20 degrees. As a result of the domain rotation, the actin molecule in the filament is flat. The flat form is essential for the formation of stable, helical F-actin. Our F-actin structure model provides the basis for understanding actin polymerization as well as its molecular interactions with actin-binding proteins.
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===Model for the F-actin structure===
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The nature of the globular- to fibrous-actin transition.,Oda T, Iwasa M, Aihara T, Maeda Y, Narita A Nature. 2009 Jan 22;457(7228):441-5. PMID:19158791<ref>PMID:19158791</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2zwh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19158791}}, adds the Publication Abstract to the page
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*[[Actin 3D structures|Actin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19158791 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19158791}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2ZWH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZWH OCA].
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==Reference==
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<ref group="xtra">PMID:19158791</ref><references group="xtra"/>
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Aihara, T.]]
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[[Category: Aihara T]]
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[[Category: Iwasa, M.]]
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[[Category: Iwasa M]]
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[[Category: Maeda, Y.]]
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[[Category: Maeda Y]]
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[[Category: Narita, A.]]
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[[Category: Narita A]]
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[[Category: Oda, T.]]
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[[Category: Oda T]]
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[[Category: Acetylation]]
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[[Category: Atp-binding]]
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[[Category: Contractile protein]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Cytoskelton]]
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[[Category: F-actin]]
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[[Category: Fiber-diffraction]]
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[[Category: G-actin]]
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[[Category: Methylation]]
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[[Category: Muscle protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 08:56:14 2010''
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Current revision

Model for the F-actin structure

PDB ID 2zwh

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