5jh7
From Proteopedia
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==Tubulin-Eribulin complex== | ==Tubulin-Eribulin complex== | ||
- | <StructureSection load='5jh7' size='340' side='right' caption='[[5jh7]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='5jh7' size='340' side='right'caption='[[5jh7]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5jh7]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5jh7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JH7 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03S:METHANESULFONIC+ACID'>03S</scene>, <scene name='pdbligand=6K9:(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-AMINO-2-HYDROXYPROPYL]-21-METHOXY-14-METHYL-8,15-DIMETHYLIDENE-2,19,30,34,37,39,40,41-OCTAOXANONACYCLO[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]HENTETRACONTAN-24-ONE+(NON-PREFERRED+NAME)'>6K9</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03S:METHANESULFONIC+ACID'>03S</scene>, <scene name='pdbligand=6K9:(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-AMINO-2-HYDROXYPROPYL]-21-METHOXY-14-METHYL-8,15-DIMETHYLIDENE-2,19,30,34,37,39,40,41-OCTAOXANONACYCLO[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]HENTETRACONTAN-24-ONE+(NON-PREFERRED+NAME)'>6K9</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jh7 OCA], [https://pdbe.org/5jh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jh7 RCSB], [https://www.ebi.ac.uk/pdbsum/5jh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jh7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Line 18: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5jh7" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5jh7" style="background-color:#fffaf0;"></div> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Stathmin-4 3D structures|Stathmin-4 3D structures]] | ||
+ | *[[Tubulin 3D Structures|Tubulin 3D Structures]] | ||
+ | *[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
- | [[Category: Akhmanova | + | [[Category: Gallus gallus]] |
- | [[Category: Bargsten | + | [[Category: Large Structures]] |
- | [[Category: Cox | + | [[Category: Rattus norvegicus]] |
- | [[Category: Custar | + | [[Category: Akhmanova A]] |
- | [[Category: Doodhi | + | [[Category: Band Horwitz S]] |
- | [[Category: Grigoriev | + | [[Category: Bargsten K]] |
- | [[Category: Hilbert | + | [[Category: Cox D]] |
- | + | [[Category: Custar DW]] | |
- | [[Category: Hua | + | [[Category: Doodhi H]] |
- | [[Category: Jiang | + | [[Category: Grigoriev I]] |
- | [[Category: Kapitein | + | [[Category: Hilbert M]] |
- | [[Category: Katrukha | + | [[Category: Hua S]] |
- | [[Category: Prota | + | [[Category: Jiang K]] |
- | [[Category: Rodriguez-Garcia | + | [[Category: Kapitein LC]] |
- | [[Category: Steinmetz | + | [[Category: Katrukha EA]] |
- | [[Category: Xiao | + | [[Category: Prota AE]] |
- | [[Category: Yang | + | [[Category: Rodriguez-Garcia R]] |
- | + | [[Category: Steinmetz MO]] | |
- | + | [[Category: Xiao H]] | |
- | + | [[Category: Yang C-PH]] | |
- | + |
Current revision
Tubulin-Eribulin complex
|
Categories: Bos taurus | Gallus gallus | Large Structures | Rattus norvegicus | Akhmanova A | Band Horwitz S | Bargsten K | Cox D | Custar DW | Doodhi H | Grigoriev I | Hilbert M | Hua S | Jiang K | Kapitein LC | Katrukha EA | Prota AE | Rodriguez-Garcia R | Steinmetz MO | Xiao H | Yang C-PH