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5jnn

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Revision as of 18:59, 20 September 2023

Crystal structure of abscisic acid receptor PYL2 in complex with Phaseic acid.

Structural highlights

5jnn is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYL2_ARATH Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.^[1] ^[2]

Publication Abstract from PubMed

Classically, hormones elicit specific cellular responses by activating dedicated receptors. Nevertheless, the biosynthesis and turnover of many of these hormone molecules also produce chemically related metabolites. These molecules may also possess hormonal activities; therefore, one or more may contribute to the adaptive plasticity of signaling outcomes in host organisms. Here, we show that a catabolite of the plant hormone abscisic acid (ABA), namely phaseic acid (PA), likely emerged in seed plants as a signaling molecule that fine-tunes plant physiology, environmental adaptation, and development. This trait was facilitated by both the emergence-selection of a PA reductase that modulates PA concentrations and by the functional diversification of the ABA receptor family to perceive and respond to PA. Our results suggest that PA serves as a hormone in seed plants through activation of a subset of ABA receptors. This study demonstrates that the co-evolution of hormone metabolism and signaling networks can expand organismal resilience.

Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity.,Weng JK, Ye M, Li B, Noel JP Cell. 2016 Aug 11;166(4):881-93. doi: 10.1016/j.cell.2016.06.027. PMID:27518563^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730
↑ Weng JK, Ye M, Li B, Noel JP. Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity. Cell. 2016 Aug 11;166(4):881-93. doi: 10.1016/j.cell.2016.06.027. PMID:27518563 doi:http://dx.doi.org/10.1016/j.cell.2016.06.027

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5jnn"

Categories: Arabidopsis thaliana | Large Structures | Noel JP | Weng JK

@@ Line 3: / Line 3: @@
 <StructureSection load='5jnn' size='340' side='right'caption='[[5jnn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5jnn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5jnn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JNN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LM:(3S,4E)-5-[(1R,5R,8S)-8-HYDROXY-1,5-DIMETHYL-3-OXO-6-OXABICYCLO[3.2.1]OCTAN-8-YL]-3-METHYLPENT-4-ENOIC+ACID'>6LM</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jo1|5jo1]], [[5jo2|5jo2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LM:(3S,4E)-5-[(1R,5R,8S)-8-HYDROXY-1,5-DIMETHYL-3-OXO-6-OXABICYCLO[3.2.1]OCTAN-8-YL]-3-METHYLPENT-4-ENOIC+ACID'>6LM</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYL2, RCAR14, At2g26040, T19L18.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnn OCA], [https://pdbe.org/5jnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jnn RCSB], [https://www.ebi.ac.uk/pdbsum/5jnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnn ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnn OCA], [http://pdbe.org/5jnn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnn RCSB], [http://www.ebi.ac.uk/pdbsum/5jnn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnn ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
+[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 27: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Arath]]
+[[Category: Arabidopsis thaliana]]
 [[Category: Large Structures]]
-[[Category: Noel, J P]]
+[[Category: Noel JP]]
-[[Category: Weng, J K]]
+[[Category: Weng JK]]
-[[Category: Aba receptor]]
-[[Category: Phaseic acid]]
-[[Category: Pyr/pyl]]
-[[Category: Signaling protein]]

5jnn

From Proteopedia

Revision as of 18:59, 20 September 2023

Crystal structure of abscisic acid receptor PYL2 in complex with Phaseic acid.

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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