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8i91

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'''Unreleased structure'''
 
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The entry 8i91 is ON HOLD
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==ACE2-SIT1 complex bound with proline==
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<StructureSection load='8i91' size='340' side='right'caption='[[8i91]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Li, Y.N., Zhang, Y.Y., Shen, Y.P., Yan, R.H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8i91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I91 FirstGlance]. <br>
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Description: ACE2-SIT1 complex bound with proline
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Shen, Y.P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i91 OCA], [https://pdbe.org/8i91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i91 RCSB], [https://www.ebi.ac.uk/pdbsum/8i91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i91 ProSAT]</span></td></tr>
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[[Category: Li, Y.N]]
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</table>
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[[Category: Yan, R.H]]
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== Function ==
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[[Category: Zhang, Y.Y]]
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[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li YN]]
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[[Category: Shen YP]]
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[[Category: Yan RH]]
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[[Category: Zhang YY]]

Current revision

ACE2-SIT1 complex bound with proline

PDB ID 8i91

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OCA

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